Some HPLC systems use as many as 4 different phases. Two safety cap kits are available for use with gradient HPLC systems (up to quaternary): one that contains 4 caps with 3 ports each, one that includes two 2-port and one 3-port VICI cap.
Specs
Connections: 1/4-28
Part
Material
Closure
Polypropylene
Insert
PTFE
O-ring
EPDM
Nuts
PPS
Ferrules
ETFE
Sleeves
Polypropylene
More information about the chemical resistance of these materials: